To safely run antivirus on HyperV Hosts you will need to whitelist some locations so they are not scanned by your Antivirus Software:

C:\ClusterStorage;
%windir%\SoftwareDistribution\DataStore\DataStore.edb;
%windir%\SoftwareDistribution\DataStore\Logs\*.log;
%windir%\SoftwareDistribution\DataStore\Logs\*.jrs;
%windir%\SoftwareDistribution\DataStore\Logs\*.chk;
%windir%\SoftwareDistribution\DataStore\Logs\*.edb;
%windir%\Security\Database\*.edb;
%windir%\Security\Database\*.sdb;
%windir%\Security\Database\*.log;
%windir%\Security\Database\*.chk;
%windir%\Security\Database\*.jrs;
%SystemRoot%\System32\GroupPolicy\registry.pol;
%ALLUSERSPROFILE%\NTuser.pol;
%PROGRAMDATA%\Microsoft\Windows\Hyper-V;